Ontology highlight
ABSTRACT:
SUBMITTER: Metayer C
PROVIDER: S-EPMC3744066 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Metayer Catherine C Scélo Ghislaine G Chokkalingam Anand P AP Barcellos Lisa F LF Aldrich Melinda C MC Chang Jeffrey S JS Guha Neela N Urayama Kevin Y KY Hansen Helen M HM Block Gladys G Kiley Vincent V Wiencke John K JK Wiemels Joseph L JL Buffler Patricia A PA
Cancer causes & control : CCC 20110712 9
<h4>Objective</h4>Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk.<h4>Methods</h4>Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, ...[more]