PPIcons: identification of protein-protein interaction sites in selected organisms.

ABSTRACT: The physico-chemical properties of interaction interfaces have a crucial role in characterization of protein-protein interactions (PPI). In silico prediction of participating amino acids helps to identify interface residues for further experimental verification using mutational analysis, or inhibition studies by screening library of ligands against given protein. Given the unbound structure of a protein and the fact that it forms a complex with another known protein, the objective of this work is to identify the residues that are involved in the interaction. We attempt to predict interaction sites in protein complexes using local composition of amino acids together with their physico-chemical characteristics. The local sequence segments (LSS) are dissected from the protein sequences using

SUBMITTER: Sriwastava BK 

PROVIDER: S-EPMC3744667 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature