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ABSTRACT:
SUBMITTER: Molodtsov V
PROVIDER: S-EPMC3745299 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Molodtsov Vadim V Nawarathne Irosha N IN Scharf Nathan T NT Kirchhoff Paul D PD Showalter H D Hollis HD Garcia George A GA Murakami Katsuhiko S KS
Journal of medicinal chemistry 20130531 11
Rifampin, a semisynthetic rifamycin, is the cornerstone of current tuberculosis treatment. Among many semisynthetic rifamycins, benzoxazinorifamycins have great potential for TB treatment due to their superior affinity for wild-type and rifampin-resistant Mycobacterium tuberculosis RNA polymerases and their reduced hepatic Cyp450 induction activity. In this study, we have determined the crystal structures of the Escherichia coli RNA polymerase complexes with two benzoxazinorifamycins. The ansa-n ...[more]