Ontology highlight
ABSTRACT:
SUBMITTER: Madan E
PROVIDER: S-EPMC3745406 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Madan Esha E Gogna Rajan R Keppler Bernhard B Pati Uttam U
PloS one 20130816 8
p53 and calcium signaling are inter-dependent and are known to show both synergistic and antagonistic effects on each other in the cellular environment. However, no molecular mechanism or cellular pathway is known which shows direct regulation between these important cellular signaling molecules. Here we have shown that in cancer cells treated with anti-neoplastic drug GaQ3, p53, there is an increase in intracellular calcium levels by transcriptional regulation of a novel calcium channel gene TR ...[more]