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Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models.

ABSTRACT: We attached the pathogen associated molecular pattern Kdo(2)-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophages in vitro and they have potent immunostimulatory activity in vivo.

SUBMITTER: Barr TA 

PROVIDER: S-EPMC3745604 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models.

Barr Tom A TA   Krembuszewski Martin M   Gupta Manish M   Gray David D   Mareque-Rivas Juan C JC  

Molecular bioSystems 20100420 9

We attached the pathogen associated molecular pattern Kdo(2)-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophages in vitro and they have potent immunostimulatory activity in vivo. ...[more]