Ontology highlight
ABSTRACT:
SUBMITTER: Cox AG
PROVIDER: S-EPMC3745641 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Cox Andrew G AG Pearson Andree G AG Pullar Juliet M JM Jönsson Thomas J TJ Lowther W Todd WT Winterbourn Christine C CC Hampton Mark B MB
The Biochemical journal 20090612 1
The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid formed during the catalytic cycle reacts with hydrogen peroxide. In the present study, Western blot methodology was developed to quantify hyperoxidation of individual 2-Cys Prxs in cells. It revealed that Prx 1 and 2 were hyperoxidized at lower doses of hydrogen peroxide than would be predicted from in vitro data, suggesting intracellular facto ...[more]