Ontology highlight
ABSTRACT:
SUBMITTER: Calabrese G
PROVIDER: S-EPMC6745495 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Calabrese Gaetano G Peker Esra E Amponsah Prince Saforo PS Hoehne Michaela Nicole MN Riemer Trine T Mai Marie M Bienert Gerd Patrick GP Deponte Marcel M Morgan Bruce B Riemer Jan J
The EMBO journal 20190807 18
Hydrogen peroxide (H<sub>2</sub> O<sub>2</sub> ) plays important roles in cellular signaling, yet nonetheless is toxic at higher concentrations. Surprisingly, the mechanism(s) of cellular H<sub>2</sub> O<sub>2</sub> toxicity remain poorly understood. Here, we reveal an important role for mitochondrial 1-Cys peroxiredoxin from budding yeast, Prx1, in regulating H<sub>2</sub> O<sub>2</sub> -induced cell death. We show that Prx1 efficiently transfers oxidative equivalents from H<sub>2</sub> O<sub>2 ...[more]