Ontology highlight
ABSTRACT:
SUBMITTER: Gagliardi A
PROVIDER: S-EPMC3746198 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Gagliardi Alessia A Mullin Nicholas P NP Ying Tan Zi Z Colby Douglas D Kousa Anastasia I AI Halbritter Florian F Weiss Jason T JT Felker Anastasia A Bezstarosti Karel K Favaro Rebecca R Demmers Jeroen J Nicolis Silvia K SK Tomlinson Simon R SR Poot Raymond A RA Chambers Ian I
The EMBO journal 20130726 16
Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog protein level. However, the protein partners of Nanog that function to direct self-renewal are unclear. Here, we identify a Nanog interactome of over 130 proteins including transcription factors, chromatin modifying complexes, phosphorylation and ubiquitination enzymes, basal transcriptional machinery members, and RNA processing factors. Sox2 was identified as a robust interacting partner of Nanog. The purified Nanog-Sox ...[more]