Ontology highlight
ABSTRACT:
SUBMITTER: Broere N
PROVIDER: S-EPMC3746809 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Broere N N Chen M M Cinar A A Singh A K AK Hillesheim J J Riederer B B Lünnemann M M Rottinghaus I I Krabbenhöft A A Engelhardt R R Rausch B B Weinman E J EJ Donowitz M M Hubbard A A Kocher O O de Jonge H R HR Hogema B M BM Seidler U U
Pflugers Archiv : European journal of physiology 20080829 5
We investigated the role of the Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) on intestinal salt and water absorption, brush border membrane (BBM) morphology, and on the NHE3 mRNA expression, protein abundance, and transport activity in the murine intestine. NHERF1-deficient mice displayed reduced jejunal fluid absorption in vivo, as well as an attenuated in vitro Na(+) absorption in isolated jejunal and colonic, but not of ileal, mucosa. However, cAMP-mediated inhibition of both parameters ...[more]