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Changes in effective connectivity by propofol sedation.

ABSTRACT: Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of consciousness. We used Dynamic Causal Modeling for fMRI (fMRI-DCM) to assess how causal connectivity is influenced by the anesthetic agent in the auditory system. Our results suggest that the dynamic observed in the auditory system during unconsciousness induced by propofol, can result in a mixture of two effects: a local inhibitory connectivity increase and a decrease in the effective connectivity in sensory cortices.

SUBMITTER: Gomez F

PROVIDER: S-EPMC3747149 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Changes in effective connectivity by propofol sedation.

Gómez Francisco F Phillips Christophe C Soddu Andrea A Boly Melanie M Boveroux Pierre P Vanhaudenhuyse Audrey A Bruno Marie-Aurélie MA Gosseries Olivia O Bonhomme Vincent V Laureys Steven S Noirhomme Quentin Q

PloS one 20130819 8

Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of c ...[more]

PMID: 23977030

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Changes in resting neural connectivity during propofol sedation.

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Propofol-induced Changes in ?-? Sensorimotor Cortical Connectivity.

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Network Properties in Transitions of Consciousness during Propofol-induced Sedation.

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Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.

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Impact of propofol sedation versus opioid/benzodiazepine sedation on colonoscopy outcomes: a systematic review with meta-analysis.

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| S-EPMC7247890 | biostudies-literature

Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans.

Project description:The adjustment of maladaptive thoughts and behaviors associated with emotional memories is central to treating psychiatric disorders. Recent research, predominantly with laboratory animals, indicates that memories can become temporarily sensitive to modification following reactivation, before undergoing reconsolidation. A method to selectively impair reconsolidation of specific emotional or traumatic memories in humans could translate to an effective treatment for conditions such as posttraumatic stress disorder. We tested whether deep sedation could impair emotional memory reconsolidation in 50 human participants. Administering the intravenous anesthetic propofol following memory reactivation disrupted memory for the reactivated, but not for a non-reactivated, slideshow story. Propofol impaired memory for the reactivated story after 24 hours, but not immediately after propofol recovery. Critically, memory impairment occurred selectively for the emotionally negative phase of the reactivated story. One dose of propofol following memory reactivation selectively impaired subsequent emotional episodic memory retrieval in a time-dependent manner, consistent with reconsolidation impairment.

| S-EPMC6426467 | biostudies-literature

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