Ontology highlight
ABSTRACT:
SUBMITTER: Redler A
PROVIDER: S-EPMC3747152 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Redler Adriano A Di Rocco Giorgio G Giannotti Domenico D Frezzotti Francesca F Bernieri Maria Giulia MG Ceccarelli Simona S D'Amici Sirio S Vescarelli Enrica E Mitterhofer Anna Paola AP Angeloni Antonio A Marchese Cinzia C
PloS one 20130819 8
Fibroblast growth factor receptor-2 (FGFR-2) plays an important role in tumorigenesis. In thyroid cancer it has been observed a FGFR-2 down-modulation, but the role of this receptor has not been yet clarified. Therefore, we decided to examine the expression of both FGFR-2 isoform, FGFR-2-IIIb and FGFR-2-IIIc, in different histological thyroid variants such as hyperplasia, follicular adenoma and papillary carcinoma. Immunohistochemistry and quantitative Real-Time PCR analyses were performed on sa ...[more]