Ontology highlight
ABSTRACT:
SUBMITTER: Das SR
PROVIDER: S-EPMC3747226 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Das Suman R SR Hensley Scott E SE Ince William L WL Brooke Christopher B CB Subba Anju A Delboy Mark G MG Russ Gustav G Gibbs James S JS Bennink Jack R JR Yewdell Jonathan W JW
Cell host & microbe 20130301 3
Human influenza A virus (IAV) vaccination is limited by "antigenic drift," rapid antibody-driven escape reflecting amino acid substitutions in the globular domain of hemagglutinin (HA), the viral attachment protein. To better understand drift, we used anti-hemagglutinin monoclonal Abs (mAbs) to sequentially select IAV escape mutants. Twelve selection steps, each resulting in a single amino acid substitution in the hemagglutinin globular domain, were required to eliminate antigenicity defined by ...[more]