Ontology highlight
ABSTRACT:
SUBMITTER: Altman MO
PROVIDER: S-EPMC5863095 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Altman Meghan O MO Angeletti Davide D Yewdell Jonathan W JW
Viral immunology 20180122 2
Influenza A virus (IAV) imposes a significant socioeconomic burden on humanity. Vaccination is effective in only 60% of individuals, even under optimal circumstances. The difficulty stems from the remarkable ability of IAV to evade existing immunity. IAV's error prone polymerase enables the rapid antigenic evolution of the two virion surface glycoproteins, neuraminidase and hemagglutinin (HA). Since the most potent antibodies (Abs) at neutralizing viral infectivity are directed the head of the H ...[more]