Ontology highlight
ABSTRACT:
SUBMITTER: Hu QH
PROVIDER: S-EPMC3747510 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Hu Qing-Hua QH Liu Ru-Juan RJ Fang Zhi-Peng ZP Zhang Jiong J Ding Ying-Ying YY Tan Min M Wang Meng M Pan Wei W Zhou Hu-Chen HC Wang En-Duo ED
Scientific reports 20130101
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl-tRNA synthetase (LeuRS) plays an essential role in cellular translation and is an attractive drug target for antimicrobial development. Here we report the compound ZCL039, a benzoxaborole-based derivative of AN2690, as a potent anti-pneumococcal agent that inhibits S. pneumoniae LeuRS (SpLeuRS) activity. We show using ...[more]