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Chemical detoxification of small molecules by Caenorhabditis elegans.

ABSTRACT: Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3'-O-phosphorylation of the resulting glucosides. The resulting glucosylated derivatives have significantly reduced toxicity to C. elegans, suggesting that these chemical modifications represent a general mechanism for worms to detoxify their environments.

SUBMITTER: Stupp GS

PROVIDER: S-EPMC3747836 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Chemical detoxification of small molecules by Caenorhabditis elegans.

Stupp Gregory S GS von Reuss Stephan H SH Izrayelit Yevgeniy Y Ajredini Ramadan R Schroeder Frank C FC Edison Arthur S AS

ACS chemical biology 20121126 2

Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3'-O-phosphorylation of the resulting glucosides. The resulting glucosylated derivatives have significantly reduced toxicity to C. elegans, suggesting that these chemical modifications represent a general mechanism for worms to detoxify their environment ...[more]

PMID: 23163740

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