Pirt functions as an endogenous regulator of TRPM8.
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ABSTRACT:
SUBMITTER: Tang Z
PROVIDER: S-EPMC3748931 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Pirt functions as an endogenous regulator of TRPM8.
Tang Zongxiang Z Kim Andrew A Masuch Thorsten T Park Kyoungsook K Weng Haojui H Wetzel Christian C Dong Xinzhong X
Nature communications 20130101
Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain. The broad expression of Pirt among dorsal root ganglion neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sensor TRPM8. The discrepancies in the channel properties of TRPM8 in native neurons versus heterologous c ...[more]
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