Ontology highlight
ABSTRACT:
SUBMITTER: Kim AY
PROVIDER: S-EPMC2605970 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Kim Andrew Y AY Tang Zongxiang Z Liu Qin Q Patel Kush N KN Maag David D Geng Yixun Y Dong Xinzhong X
Cell 20080501 3
Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of noxious heat and capsaicin. Its channel activity can be modulated by several mechanisms. Here we identify a membrane protein, Pirt, as a regulator of TRPV1. Pirt is expressed in most nociceptive neurons in the dorsal root ganglia (DRG) including TRPV1-positive cells. Pirt null mice show impaired responsiveness to noxious heat and capsaicin. Noxious heat- and capsaicin-sensitive currents in Pirt-deficient DRG neurons are si ...[more]