Unknown

Dataset Information

0

A genome-wide association study of breast cancer in women of African ancestry.

ABSTRACT: Genome-wide association studies (GWAS) in diverse populations are needed to reveal variants that are more common and/or limited to defined populations. We conducted a GWAS of breast cancer in women of African ancestry, with genotyping of >1,000,000 SNPs in 3,153 African American cases and 2,831 controls, and replication testing of the top 66 associations in an additional 3,607 breast cancer cases and 11,330 controls of African ancestry. Two of the 66 SNPs replicated (p < 0.05) in stage 2, which reached statistical significance levels of 10(-6) and 10(-5) in the stage 1 and 2 combined analysis (rs4322600 at chromosome 14q31: OR = 1.18, p = 4.3 × 10(-6); rs10510333 at chromosome 3p26: OR = 1.15, p = 1.5 × 10(-5)). These suggestive risk loci have not been identified in previous GWAS in other populations and will need to be examined in additional samples. Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample.

SUBMITTER: Chen F 

PROVIDER: S-EPMC3749077 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A genome-wide association study of breast cancer in women of African ancestry.

Chen Fang F   Chen Gary K GK   Stram Daniel O DO   Millikan Robert C RC   Ambrosone Christine B CB   John Esther M EM   Bernstein Leslie L   Zheng Wei W   Palmer Julie R JR   Hu Jennifer J JJ   Rebbeck Tim R TR   Ziegler Regina G RG   Nyante Sarah S   Bandera Elisa V EV   Ingles Sue A SA   Press Michael F MF   Ruiz-Narvaez Edward A EA   Deming Sandra L SL   Rodriguez-Gil Jorge L JL   Demichele Angela A   Chanock Stephen J SJ   Blot William W   Signorello Lisa L   Cai Qiuyin Q   Li Guoliang G   Long Jirong J   Huo Dezheng D   Zheng Yonglan Y   Cox Nancy J NJ   Olopade Olufunmilayo I OI   Ogundiran Temidayo O TO   Adebamowo Clement C   Nathanson Katherine L KL   Domchek Susan M SM   Simon Michael S MS   Hennis Anselm A   Nemesure Barbara B   Wu Suh-Yuh SY   Leske M Cristina MC   Ambs Stefan S   Hutter Carolyn M CM   Young Alicia A   Kooperberg Charles C   Peters Ulrike U   Rhie Suhn K SK   Wan Peggy P   Sheng Xin X   Pooler Loreall C LC   Van Den Berg David J DJ   Le Marchand Loic L   Kolonel Laurence N LN   Henderson Brian E BE   Haiman Christopher A CA  

Human genetics 20120825 1

Genome-wide association studies (GWAS) in diverse populations are needed to reveal variants that are more common and/or limited to defined populations. We conducted a GWAS of breast cancer in women of African ancestry, with genotyping of >1,000,000 SNPs in 3,153 African American cases and 2,831 controls, and replication testing of the top 66 associations in an additional 3,607 breast cancer cases and 11,330 controls of African ancestry. Two of the 66 SNPs replicated (p < 0.05) in stage 2, which  ...[more]

Similar Datasets

Unknown Genome-Wide Association Study of Breast Density among Women of African Ancestry.
| S-EPMC10216271 | biostudies-literature
Unknown Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers.
| S-EPMC3697898 | biostudies-literature
Unknown Evaluating genome-wide association study-identified breast cancer risk variants in African-American women.
| S-EPMC3620157 | biostudies-literature
Unknown A genome-wide association study on African-ancestry populations for asthma.
| S-EPMC3606015 | biostudies-literature
Unknown Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer.
| S-EPMC5975608 | biostudies-literature
Unknown Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.
| S-EPMC5292212 | biostudies-literature
Unknown Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
| S-EPMC3102788 | biostudies-literature
Unknown Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
| S-EPMC3888262 | biostudies-literature
Unknown A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.
| S-EPMC6960456 | biostudies-literature
Unknown Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry.
| S-EPMC5500414 | biostudies-literature