Ontology highlight
ABSTRACT:
SUBMITTER: Werner A
PROVIDER: S-EPMC3749308 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Werner Achim A Disanza Andrea A Reifenberger Nina N Habeck Gregor G Becker Janina J Calabrese Matthew M Urlaub Henning H Lorenz Holger H Schulman Brenda B Scita Giorgio G Melchior Frauke F
Nature cell biology 20130113 2
Eps8, a bi-functional actin cytoskeleton remodeller, is a positive regulator of cell proliferation and motility. Here, we describe an unrecognized mechanism regulating Eps8 that is required for proper mitotic progression: whereas Eps8 is stable in G1 and S phase, its half-life drops sharply in G2. This requires G2-specific proteasomal degradation mediated by the ubiquitin E3 ligase SCF(Fbxw5). Consistent with a short window of degradation, Eps8 disappears from the cell cortex early in mitosis, b ...[more]