Ontology highlight
ABSTRACT:
SUBMITTER: Palazzo L
PROVIDER: S-EPMC4013160 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Palazzo Luca L Della Monica Rosa R Visconti Roberta R Costanzo Vincenzo V Grieco Domenico D
Cell cycle (Georgetown, Tex.) 20140206 7
The recessive ataxia-telangiectasia (A-T) syndrome is characterized by cerebellar degeneration, immunodeficiency, cancer susceptibility, premature aging, and insulin-resistant diabetes and is caused by loss of function of the ATM kinase, a member of the phosphoinositide 3-kinase-like protein kinases (PIKKs) family. ATM plays a crucial role in the DNA damage response (DDR); however, the complexity of A-T features suggests that ATM may regulate other cellular functions. Here we show that ATM affec ...[more]