Rigid DNA beams for high-resolution single-molecule mechanics.
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ABSTRACT:
SUBMITTER: Pfitzner E
PROVIDER: S-EPMC3749440 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Rigid DNA beams for high-resolution single-molecule mechanics.
Pfitzner Emanuel E Wachauf Christian C Kilchherr Fabian F Pelz Benjamin B Shih William M WM Rief Matthias M Dietz Hendrik H
Angewandte Chemie (International ed. in English) 20130621 30
Bridging the gap: Rigid DNA linkers (blue, see picture) between microspheres (green) for high-resolution single-molecule mechanical experiments were constructed using DNA origami. The resulting DNA helical bundles greatly reduce the noise generated in studies of conformation changes using optical tweezers and were applied to study small DNA secondary structures. ...[more]
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