Rolling-circle transposons in eukaryotes.
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ABSTRACT:
SUBMITTER: Kapitonov VV
PROVIDER: S-EPMC37501 | biostudies-literature | 2001 Jul
REPOSITORIES: biostudies-literature
Publications
Rolling-circle transposons in eukaryotes.
Proceedings of the National Academy of Sciences of the United States of America 20010710 15
All eukaryotic DNA transposons reported so far belong to a single category of elements transposed by the so-called "cut-and-paste" mechanism. Here, we report a previously unknown category of eukaryotic DNA transposons, Helitron, which transpose by rolling-circle replication. Autonomous Helitrons encode a 5'-to-3' DNA helicase and nuclease/ligase similar to those encoded by known rolling-circle replicons. Helitron-like transposons have conservative 5'-TC and CTRR-3' termini and do not have termin ...[more]
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