Ontology highlight
ABSTRACT:
SUBMITTER: Postow MA
PROVIDER: S-EPMC3751414 | biostudies-literature | 2012 Mar-Apr
REPOSITORIES: biostudies-literature
Postow Michael A MA Harding James J Wolchok Jedd D JD
Cancer journal (Sudbury, Mass.) 20120301 2
Insight into the mechanisms of anti-tumor immunity has generated great enthusiasm for the treatment of patients with advanced melanoma. Particularly, negative regulators of the immune system, called immunologic checkpoints, have been found to play important roles in restraining otherwise effective anti-tumor immunologic responses. Therapies that target these negative regulator checkpoints, such as those directed against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 receptor (P ...[more]