Ontology highlight
ABSTRACT:
SUBMITTER: Efremova M
PROVIDER: S-EPMC5750210 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Efremova Mirjana M Rieder Dietmar D Klepsch Victoria V Charoentong Pornpimol P Finotello Francesca F Hackl Hubert H Hermann-Kleiter Natascha N Löwer Martin M Baier Gottfried G Krogsdam Anne A Trajanoski Zlatko Z
Nature communications 20180102 1
The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we elucidate the impact of evolutionary and immune-related forces on editing the tumor in a mouse model for hypermutated and microsatellite-instable colorectal cancer. Analyses of wild-type and immunodeficient RAG1 knockout mice transplanted with MC38 cells reveal that upregulation of checkpoint molecules and infiltrat ...[more]