Ontology highlight
ABSTRACT:
SUBMITTER: Limapichat W
PROVIDER: S-EPMC3751542 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Limapichat Walrati W Yu Wesley Y WY Branigan Emma E Lester Henry A HA Dougherty Dennis A DA
ACS chemical neuroscience 20121207 2
Memantine (Namenda) is prescribed as a treatment for moderate to severe Alzheimer's Disease. Memantine functions by blocking the NMDA receptor, but the key binding interactions between drug and receptor are not fully elucidated. To determine key binding interactions of memantine, we made side-by-side comparisons of IC(50) for memantine and amantadine, a structurally related drug, in the GluN1/GluN2B NMDA receptor. We identified hydrophobic binding pockets for the two methyl groups on memantine f ...[more]