Dysregulated methylation at imprinted genes in prostate tumor tissue detected by methylation microarray.
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ABSTRACT:
SUBMITTER: Jacobs DI
PROVIDER: S-EPMC3751920 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Dysregulated methylation at imprinted genes in prostate tumor tissue detected by methylation microarray.
Jacobs Daniel I DI Mao Yingying Y Fu Alan A Kelly William Kevin WK Zhu Yong Y
BMC urology 20130726
<h4>Background</h4>Imprinting is an important epigenetic regulator of gene expression that is often disrupted in cancer. While loss of imprinting (LOI) has been reported for two genes in prostate cancer (IGF2 and TFPI2), disease-related changes in methylation across all imprinted gene regions has not been investigated.<h4>Methods</h4>Using an Illumina Infinium Methylation Assay, we analyzed methylation of 396 CpG sites in the promoter regions of 56 genes in a pooled sample of 12 pairs of prostat ...[more]
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