Ontology highlight
ABSTRACT:
SUBMITTER: Fournier C
PROVIDER: S-EPMC136958 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Fournier Cécile C Goto Yuji Y Ballestar Esteban E Delaval Katia K Hever Ann M AM Esteller Manel M Feil Robert R
The EMBO journal 20021201 23
In different eukaryotic model systems, chromatin and gene expression are modulated by post-translational modification of histone tails. In this in vivo study, histone methylation and acetylation are investigated along the imprinted mouse genes Snrpn, Igf2r and U2af1-rs1. These imprinted genes all have a CpG-rich regulatory element at which methylation is present on the maternal allele, and originates from the female germ line. At these 'differentially methylated regions' (DMRs), histone H3 on th ...[more]