Ontology highlight
ABSTRACT:
SUBMITTER: Rillahan CD
PROVIDER: S-EPMC3751994 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Rillahan Cory D CD Schwartz Erik E Rademacher Christoph C McBride Ryan R Rangarajan Janani J Fokin Valery V VV Paulson James C JC
ACS chemical biology 20130424 7
The Siglec family of sialic acid-binding proteins are differentially expressed on white blood cells of the immune system and represent an attractive class of targets for cell-directed therapy. Nanoparticles decorated with high-affinity Siglec ligands show promise for delivering cargo to Siglec-bearing cells, but this approach has been limited by a lack of ligands with suitable affinity and selectivity. Building on previous work employing solution-phase sialoside library synthesis and subsequent ...[more]