Embedding A?42 in heterogeneous membranes depends on cholesterol asymmetries.
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ABSTRACT:
SUBMITTER: Liguori N
PROVIDER: S-EPMC3752101 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Embedding Aβ42 in heterogeneous membranes depends on cholesterol asymmetries.
Liguori Nicoletta N Nerenberg Paul S PS Head-Gordon Teresa T
Biophysical journal 20130801 4
Using a coarse-grained lipid and peptide model, we show that the free energy stabilization of amyloid-β in heterogeneous lipid membranes is predicted to have a dependence on asymmetric distributions of cholesterol compositions across the membrane leaflets. We find that a highly asymmetric cholesterol distribution that is depleted on the exofacial leaflet but enhanced on the cytofacial leaflet of the model lipid membrane thermodynamically favors membrane retention of a fully embedded Aβ peptide. ...[more]
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