Ontology highlight
ABSTRACT:
SUBMITTER: Deriu E
PROVIDER: S-EPMC3752295 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Deriu Elisa E Liu Janet Z JZ Pezeshki Milad M Edwards Robert A RA Ochoa Roxanna J RJ Contreras Heidi H Libby Stephen J SJ Fang Ferric C FC Raffatellu Manuela M
Cell host & microbe 20130701 1
Host inflammation alters the availability of nutrients such as iron to limit microbial growth. However, Salmonella enterica serovar Typhimurium thrives in the inflamed gut by scavenging for iron with siderophores. By administering Escherichia coli strain Nissle 1917, which assimilates iron by similar mechanisms, we show that this nonpathogenic bacterium can outcompete and reduce S. Typhimurium colonization in mouse models of acute colitis and chronic persistent infection. This probiotic activity ...[more]