Ontology highlight
ABSTRACT:
SUBMITTER: Keyari CM
PROVIDER: S-EPMC3752426 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Keyari Charles M CM Kearns Alison K AK Duncan Nathan S NS Eickholt Emily A EA Abbott Geoffrey G Beall Howard D HD Diaz Philippe P
Journal of medicinal chemistry 20130501 10
A series of 7-amino- and 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2-position were synthesized, characterized, and evaluated as potential NAD(P)H:quinone oxidoreductase (NQO1) -directed antitumor agents. The synthesis of lavendamycin analogues is illustrated. Metabolism studies demonstrated that 7-amino analogues were generally better substrates for NQO1 than 7-amido analogues, as were compounds with smaller heteroaromatic substituents at the C-2 position. Surprisingly, only ...[more]