Ontology highlight
ABSTRACT:
SUBMITTER: Kurisaki H
PROVIDER: S-EPMC3753263 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Kurisaki Hironori H Nagao Yukihiro Y Nagafuchi Seiho S Mitsuyama Masao M
PloS one 20130826 8
Although the autoimmune regulator (Aire) knockout (KO) mouse model has been reported to present various organ-specific autoimmune diseases depending on genetic background, autoimmune pancreatitis in mice of BALB/c background has not yet been reported. Here, we report that Aire KO mice with BALB/cAnN background showed significant lymphoid cell infiltration in the pancreas and stomach. To examine whether the phenotype in the pancreas and stomach is due to autoimmune reaction associated with autoan ...[more]