Ontology highlight
ABSTRACT:
SUBMITTER: Maskey D
PROVIDER: S-EPMC3753548 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Maskey Dipak D Yousefi Shida S Schmid Inès I Zlobec Inti I Perren Aurel A Friis Robert R Simon Hans-Uwe HU
Nature communications 20130101
Anticancer drug therapy activates both molecular cell death and autophagy pathways. Here we show that even sublethal concentrations of DNA-damaging drugs, such as etoposide and cisplatin, induce the expression of autophagy-related protein 5 (ATG5), which is both necessary and sufficient for the subsequent induction of mitotic catastrophe. We demonstrate that ATG5 translocates to the nucleus, where it physically interacts with survivin in response to DNA-damaging agents both in vitro and in carci ...[more]