Ontology highlight
ABSTRACT:
SUBMITTER: Kofman AV
PROVIDER: S-EPMC3906336 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Kofman Alexander V AV Kim Jungeun J Park So Yeon SY Dupart Evan E Letson Christopher C Bao Yongde Y Ding Kai K Chen Quan Q Schiff David D Larner James J Abounader Roger R
Cell cycle (Georgetown, Tex.) 20130919 22
Efficient and error-free DNA repair is critical for safeguarding genome integrity, yet it is also linked to radio- and chemoresistance of malignant tumors. miR-34a, a potent tumor suppressor, influences a large set of p53-regulated genes and contributes to p53-mediated apoptosis. However, the effects of miR-34a on the processes of DNA damage and repair are not entirely understood. We explored tet-inducible miR-34a-expressing human p53 wild-type and R273H p53 mutant GBM cell lines, and found that ...[more]