Ontology highlight
ABSTRACT:
SUBMITTER: Firnberg E
PROVIDER: S-EPMC3753648 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Firnberg Elad E Ostermeier Marc M
Nucleic acids research 20130610 15
An important goal of evolutionary biology is to understand the constraints that shape the dynamics and outcomes of evolution. Here, we address the extent to which the structure of the standard genetic code constrains evolution by analyzing adaptive mutations of the antibiotic resistance gene TEM-1 β-lactamase and the fitness distribution of codon substitutions in two influenza hemagglutinin inhibitor genes. We find that the architecture of the genetic code significantly constrains the adaptive e ...[more]