Ontology highlight
ABSTRACT:
SUBMITTER: Shapiro DJ
PROVIDER: S-EPMC5035594 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Shapiro David J DJ Livezey Mara M Yu Liqun L Zheng Xiaobin X Andruska Neal N
Trends in endocrinology and metabolism: TEM 20160625 10
The endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), plays a key role in regulating intracellular protein homeostasis. The extensively studied reactive mode of UPR activation is characterized by unfolded protein, or other EnR stress, triggering UPR activation. Here we focus on the emerging anticipatory mode of UPR activation in which mitogenic steroid and peptide hormones and other effectors preactivate the UPR and anticipate a future need for increased protein fol ...[more]