An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.
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ABSTRACT:
SUBMITTER: Ottoboni L
PROVIDER: S-EPMC3753678 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.
Ottoboni Linda L Keenan Brendan T BT Tamayo Pablo P Kuchroo Manik M Mesirov Jill P JP Buckle Guy J GJ Khoury Samia J SJ Hafler David A DA Weiner Howard L HL De Jager Philip L PL
Science translational medicine 20120901 153
The multiple sclerosis (MS) patient population is highly heterogeneous in terms of disease course and treatment response. We used a transcriptional profile generated from peripheral blood mononuclear cells to define the structure of an MS patient population. Two subsets of MS subjects (MS(A) and MS(B)) were found among 141 untreated subjects. We replicated this structure in two additional groups of MS subjects treated with one of the two first-line disease-modifying treatments in MS: glatiramer ...[more]
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2019-11-08 | GSE140106 | GEO