Ontology highlight
ABSTRACT:
SUBMITTER: Woo CJ
PROVIDER: S-EPMC3753906 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Woo Caroline J CJ Kharchenko Peter V PV Daheron Laurence L Park Peter J PJ Kingston Robert E RE
Molecular and cellular biology 20130617 16
Polycomb group (PcG)-mediated repression is an evolutionarily conserved process critical for cell fate determination and maintenance of gene expression during embryonic development. However, the mechanisms underlying PcG recruitment in mammals remain unclear since few regulatory sites have been identified. We report two novel prospective PcG-dependent regulatory elements within the human HOXB and HOXC clusters and compare their repressive activities to a previously identified element in the HOXD ...[more]