Ontology highlight
ABSTRACT:
SUBMITTER: Chittock EC
PROVIDER: S-EPMC5310723 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chittock Emily C EC Latwiel Sebastian S Miller Thomas C R TC Müller Christoph W CW
Biochemical Society transactions 20170201 1
The polycomb group (PcG) proteins are a large and diverse family that epigenetically repress the transcription of key developmental genes. They form three broad groups of polycomb repressive complexes (PRCs) known as PRC1, PRC2 and Polycomb Repressive DeUBiquitinase, each of which modifies and/or remodels chromatin by distinct mechanisms that are tuned by having variable compositions of core and accessory subunits. Until recently, relatively little was known about how the various PcG proteins as ...[more]