Ontology highlight
ABSTRACT:
SUBMITTER: Goyama S
PROVIDER: S-EPMC3754260 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Goyama Susumu S Schibler Janet J Cunningham Lea L Zhang Yue Y Rao Yalan Y Nishimoto Nahoko N Nakagawa Masahiro M Olsson Andre A Wunderlich Mark M Link Kevin A KA Mizukawa Benjamin B Grimes H Leighton HL Kurokawa Mineo M Liu P Paul PP Huang Gang G Mulloy James C JC
The Journal of clinical investigation 20130827 9
RUNX1 is generally considered a tumor suppressor in myeloid neoplasms. Inactivating RUNX1 mutations have frequently been found in patients with myelodysplastic syndrome (MDS) and cytogenetically normal acute myeloid leukemia (AML). However, no somatic RUNX1 alteration was found in AMLs with leukemogenic fusion proteins, such as core-binding factor (CBF) leukemia and MLL fusion leukemia, raising the possibility that RUNX1 could actually promote the growth of these leukemia cells. Using normal hum ...[more]