Ontology highlight
ABSTRACT:
SUBMITTER: Lewis AH
PROVIDER: S-EPMC7899553 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Lewis Andrew Henry AH Bridges Cory Seth CS Punia Viraaj Singh VS Cooper Abraham Fausto Jornada AFJ Puppi Monica M Lacorazza H Daniel HD
Oncotarget 20210216 4
Acute myeloid leukemia (AML) is an aggressive hematological malignancy of the bone marrow that affects mostly elderly adults. Alternative therapies are needed for AML patients because the overall prognosis with current standard of care, high dose chemotherapy and allogeneic transplantation, remains poor due to the emergence of refractory and relapsed disease. Here, we found expression of the transcription factor KLF4 in AML cell lines is not silenced through <i>KLF4</i> gene methylation nor via ...[more]