Ontology highlight
ABSTRACT:
SUBMITTER: Satory D
PROVIDER: S-EPMC3754754 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Satory Dominik D Halliday Jennifer A JA Sivaramakrishnan Priya P Lua Rhonald C RC Herman Christophe C
Journal of bacteriology 20130712 18
The auxiliary factor DksA is a global transcription regulator and, with the help of ppGpp, controls the nutritional stress response in Escherichia coli. Although the consequences of its modulation of RNA polymerase (RNAP) are becoming better explained, it is still not fully understood how the two proteins interact. We employed a series of genetic suppressor selections to find residues in RNAP that alter its sensitivity to DksA. Our approach allowed us to identify and genetically characterize in ...[more]