Ontology highlight
ABSTRACT:
SUBMITTER: Medrzycki M
PROVIDER: S-EPMC3754803 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Medrzycki Magdalena M Zhang Yunzhe Y McDonald John F JF Fan Yuhong Y
Frontiers in bioscience (Landmark edition) 20120101 2
H1 linker histones play a key role in facilitating higher order chromatin folding. Emerging evidence suggests that H1 and its multiple variants are important epigenetic factors in modulating chromatin function and gene expression. Ovarian cancer is a devastating disease, ranking the fifth leading cause of all women cancer death due to its poor prognosis and difficulty in early diagnosis. Although epigenetic alterations in ovarian cancers are being appreciated in general, the role of H1 has not b ...[more]