Directing stem cell fate by controlling the affinity and density of ligand-receptor interactions at the biomaterials interface.
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ABSTRACT:
SUBMITTER: Kilian KA
PROVIDER: S-EPMC3754806 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Directing stem cell fate by controlling the affinity and density of ligand-receptor interactions at the biomaterials interface.
Kilian Kristopher A KA Mrksich Milan M
Angewandte Chemie (International ed. in English) 20120413 20
Sticky situation: the differentiation of mesenchymal stem cells can be influenced by the affinity and density of an immobilized ligand for the integrin receptors. Cells adherent to monolayers that present the high-affinity, cyclic-RGD peptide (left) show increased expression of osteogenic markers, while cells on monolayers presenting the lower-affinity, linear-RGD peptide (right) express early markers of myogenesis at a high density and neurogenesis at a low density of the ligand. ...[more]
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