Ontology highlight
ABSTRACT:
SUBMITTER: Luo BH
PROVIDER: S-EPMC423134 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Luo Bing-Hao BH Springer Timothy A TA Takagi Junichi J
PLoS biology 20040615 6
Conformational communication across the plasma membrane between the extracellular and intracellular domains of integrins is beginning to be defined by structural work on both domains. However, the role of the alpha and beta subunit transmembrane domains and the nature of signal transmission through these domains have been elusive. Disulfide bond scanning of the exofacial portions of the integrin alpha(IIbeta) and beta(3) transmembrane domains reveals a specific heterodimerization interface in th ...[more]