Ontology highlight
ABSTRACT:
SUBMITTER: Ferraro F
PROVIDER: S-EPMC3754876 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Ferraro Francesca F Lymperi Stefania S Méndez-Ferrer Simón S Saez Borja B Spencer Joel A JA Yeap Beow Y BY Masselli Elena E Graiani Gallia G Prezioso Lucia L Rizzini Elisa Lodi EL Mangoni Marcellina M Rizzoli Vittorio V Sykes Stephen M SM Lin Charles P CP Frenette Paul S PS Quaini Federico F Scadden David T DT
Science translational medicine 20111001 104
Success with transplantation of autologous hematopoietic stem and progenitor cells (HSPCs) in patients depends on adequate collection of these cells after mobilization from the bone marrow niche by the cytokine granulocyte colony-stimulating factor (G-CSF). However, some patients fail to achieve sufficient HSPC mobilization. Retrospective analysis of bone marrow transplant patient records revealed that diabetes correlated with poor mobilization of CD34+ HSPCs. In mouse models of type 1 and type ...[more]