Ontology highlight
ABSTRACT:
SUBMITTER: Smith-Berdan S
PROVIDER: S-EPMC6895718 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Smith-Berdan Stephanie S Bercasio Alyssa A Rajendiran Smrithi S Forsberg E Camilla EC
Stem cell reports 20191010 5
Hematopoietic stem cell (HSC) transplantation is a curative treatment for a variety of blood and immune disorders. Currently available methods to obtain donor HSCs are suboptimal, and the limited supply of donor HSCs hampers the success and availability of HSC transplantation therapies. We recently showed that manipulation of vascular integrity can be employed to induce HSC mobilization from the bone marrow to the blood stream, facilitating non-invasive collection of HSCs. Here, we tested whethe ...[more]