Ontology highlight
ABSTRACT:
SUBMITTER: Kornblit B
PROVIDER: S-EPMC3755028 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Kornblit Brian B Maloney David G DG Storb Rainer R Storek Jan J Hari Parameswaran P Vucinic Vladan V Maziarz Richard T RT Chauncey Thomas R TR Pulsipher Michael A MA Bruno Benedetto B Petersen Finn B FB Bethge Wolfgang A WA Hübel Kai K Bouvier Michelle E ME Fukuda Takahiro T Storer Barry E BE Sandmaier Brenda M BM
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20130611 9
The risks and benefits of adding fludarabine to a 2-Gy total body irradiation (TBI) nonmyeloablative regimen are unknown. For this reason, we conducted a prospective randomized trial comparing 2-Gy TBI alone, or in combination with 90 mg/m(2) fludarabine (FLU/TBI), before transplantation of peripheral blood stem cells from HLA-matched related donors. Eighty-five patients with hematological malignancies were randomized to be conditioned with TBI alone (n = 44) or FLU/TBI (n = 41). All patients ha ...[more]