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Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.


ABSTRACT: Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend ? 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers.

SUBMITTER: Wyss A 

PROVIDER: S-EPMC3755640 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Wyss Annah A   Hashibe Mia M   Chuang Shu-Chun SC   Lee Yuan-Chin Amy YC   Zhang Zuo-Feng ZF   Yu Guo-Pei GP   Winn Deborah M DM   Wei Qingyi Q   Talamini Renato R   Szeszenia-Dabrowska Neonila N   Sturgis Erich M EM   Smith Elaine E   Shangina Oxana O   Schwartz Stephen M SM   Schantz Stimson S   Rudnai Peter P   Purdue Mark P MP   Eluf-Neto Jose J   Muscat Joshua J   Morgenstern Hal H   Michaluart Pedro P   Menezes Ana A   Matos Elena E   Mates Ioan Nicolae IN   Lissowska Jolanta J   Levi Fabio F   Lazarus Philip P   La Vecchia Carlo C   Koifman Sergio S   Herrero Rolando R   Hayes Richard B RB   Franceschi Silvia S   Wünsch-Filho Victor V   Fernandez Leticia L   Fabianova Eleonora E   Daudt Alexander W AW   Dal Maso Luigino L   Curado Maria Paula MP   Chen Chu C   Castellsague Xavier X   de Carvalho Marcos Brasilino MB   Cadoni Gabriella G   Boccia Stefania S   Brennan Paul P   Boffetta Paolo P   Olshan Andrew F AF  

American journal of epidemiology 20130630 5


Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking sepa  ...[more]

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