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Current and emerging treatment options for uveal melanoma.

ABSTRACT: Uveal melanoma (UM) is the most common primary malignant intraocular tumor in adults, with a 10-year cumulative metastatic rate of 34%. The most common site of metastasis is the liver (95%). Unfortunately, the current treatment of metastatic UM is limited by the lack of effective systemic therapy. Options for the management of the primary intraocular tumor include radical surgery as well as conservative treatments in order to preserve visual acuity. For metastatic disease, several approaches have been described with no standard method. Nevertheless, median survival after liver metastasis is poor, being around 4-6 months, with a 1-year survival of 10%-15%. In this review, the authors summarize current and promising new treatments for UM.

SUBMITTER: Pereira PR

PROVIDER: S-EPMC3755706 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Current and emerging treatment options for uveal melanoma.

Pereira Patricia Rusa PR Odashiro Alexandre Nakao AN Lim Li-Anne LA Miyamoto Cristina C Blanco Paula L PL Odashiro Macanori M Maloney Shawn S De Souza Dominique F DF Burnier Miguel N MN

Clinical ophthalmology (Auckland, N.Z.) 20130822

Uveal melanoma (UM) is the most common primary malignant intraocular tumor in adults, with a 10-year cumulative metastatic rate of 34%. The most common site of metastasis is the liver (95%). Unfortunately, the current treatment of metastatic UM is limited by the lack of effective systemic therapy. Options for the management of the primary intraocular tumor include radical surgery as well as conservative treatments in order to preserve visual acuity. For metastatic disease, several approaches hav ...[more]

PMID: 24003303

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Current and emerging treatment options for uveal melanoma.

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Current and emerging treatment options for uveal melanoma.

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